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David-and-Goliath story in cancer research: Summit Therapeutics' new drug triumphs against Keytruda, made by pharmaceutical giant Merck.

Few agents say they are seeing cuts in real estate commissions, so far.

The 49ers' progress report came with mostly A's and B's as they won for the first time in three weeks, 30-13 over the New England Patriots.

Manufacturers typically make 2,000 to 3,000 replica models of the Indianapolis 500 pace car that are sold through their dealers. That is the situation with our feature car today. Danville's Bill O’Connor has owned this issue's 1969 Chevrolet Camaro convertible replica for about 14 years.

The federal judge ruled that Balboa Park artist's legal challenge is "likely to succeed in showing that (the law) is unconstitutionally vague and overbroad"

A Los Angeles police officer’s unsecured rifle was sucked into a MRI machine during a botched October 2023 raid at a Van Nuys medical imaging business that was mistaken for an illegal pot operation, according to a federal lawsuit.

In the halls of power, the perception is we're a bunch of whiners. Relatives of the dead say otherwise.

Three members of the San Diego Fire-Rescue Department were seriously injured in a vehicle crash early Sunday while heading to assist in hurricane relief efforts in North Carolina, officials said.

Officials ordered a new evacuation for the Line fire Sunday, Sept. 29, nearly a month after the fire in the San Bernardino Mountains was first reported.

A day before Satrupa Kagel's flight from Tokyo to San Francisco, she finds out that American Airlines has canceled her ticket. Is she on the hook for the $3,548 that she had to spend for a last-minute ticket?